The amino acid D-Aspartic Acid (DAA) plays a complex role in the body’s endocrine system. Found in high concentrations in the gonads and pituitary, either via its synthesis there for via uptake from the blood(7), it stimulates hormonal release from those glands, including growth hormone (GH), gonadotrophin releasing hormone (GnRH), luteinizing hormone (LH) and testosterone(1). Like LH (and HCG)(6),DAA also increases testicular aromatase activity(4), promoting the conversion of testosterone to estrogen and thus balancing it’s own gonadotrophic stimulus(7). Not surprisingly, research from the lab of the most prominent researcher of DAA’s metabolic effects, Gemma D’Aniello, indicates that lower levels of DAA are associated with reduced sex cell(sperm(3)and oocyte(2)) quality in humans.
The profound role of DAA in regulating steroidogenesis prompted D’Aniello’s group to investigate the effects of oral administration of DAA in both rats and humans(7). Rats given drinking water supplemented with DAA demonstrated a ~7 fold increase in DAA in testicular and pituitary tissue, triggering an intracellular 2nd messenger (cAMP and cGMP) mechanism and elevating blood LH (~50%) and testosterone (over 100%!). Importantly, L-Aspartic acid, the amino acid found in food and a typical protein supplement, had no such hormonal effects in the rodents.
In men, a single morning dose of just over 3 grams per day (roughly equivalent to the daily rodent dose in this study(5)) increased LH (33%) and testosterone (42%) after 12 consecutive days of consumption. This effect was noted in 90% of their subjects but was not apparent after 6 days of supplementation. Additionally, blood testosterone (but not LH) was elevated for an additional 3 days after discontinuing the DAA supplement, which they suggest was likely due to residual DAA in the testes.
The limited research on DAA suggests that a single oral dose of ~3g / day begins to produce significant hormonal effects by the second week of supplementation in most men, elevating luteinizing hormone and testosterone by ~25-50%. Animal data also suggest that other pituitary hormones like GH might be increased by DAA, as well. The effects of long-term DAA consumption is not known at this time, so caution is advised. DAA could be taken alone or in conjunction with other supplements that act synergistically to elevate testosterone or have related effects (e.g., Long Jack,Tribulus Terrestris, Maca, MG’s Super Test Booster, Yohimbine, or Horny Goat Weed), that inhibit cortisol’s effects (e.g., Cissus Quandrangularis), that elevate thyroid output like (e.g., Guggulsterones), or that ameliorate the adverse effects of elevated testosterone or estrogen (e.g., 3,3’-Diindolylmethane or DIM).
Magnesium Stearate, Capsule (Vegetable Cellulose).
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1. D'AnielloA.D-Aspartic acid: an endogenous amino acid with an importantneuroendocrine role. BrainRes Rev 53:215-234, 2007.
2. D'AnielloG, Grieco N, Di Filippo MA, Cappiello F, Topo E, D'Aniello E, andRonsini S.Reproductive implication of D-aspartic acid in human pre-ovulatoryfollicular fluid. HumReprod 22:3178-3183, 2007.
3. D'AnielloG, Ronsini S, Guida F, Spinelli P, and D'Aniello A.Occurrence of D-aspartic acid in human seminal plasma andspermatozoa: possible role in reproduction. FertilSteril 84:1444-1449, 2005.
4. LamannaC, Assisi L, Botte V, and Di Fiore MM.Involvement of D-Asp in P450 aromatase activity and estrogenreceptors in boar testis.AminoAcids 32:45-51, 2007.
5. RogersVV, Wickstrom M, Liber K, and MacKinnon MD.Acute and subchronic mammalian toxicity of naphthenic acids from oilsands tailings.ToxicolSci 66:347-355, 2002.
6. RommertsFF, and Brinkman AO.Modulation of steroidogenic activities in testis Leydig cells. MolCell Endocrinol 21:15-28, 1981.
7. TopoE, Soricelli A, D'Aniello A, Ronsini S, and D'Aniello G.The role and molecular mechanism of D-aspartic acid in the releaseand synthesis of LH and testosterone in humans and rats. ReprodBiol Endocrinol 7:120, 2009.